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Candidate proteins that interact with other proteins/enzygmes
able
- Tyrosine kinase.
- Phosphorylates other proteins and regualtes their activity (including trio).
- activates trio (a GTP exchange factor)
- Regulates actin architecture
- Oncogene (BCR-Able)
- targeted by Glivec, one of the few targeted molecular medicines
- Knocking out able on its own results in neural tube defects, similar to knocking out shroom
trio
- GTP Exchange factor (GEF)
- Trio activates Rho (Rock?)
- Rho is a GTPase
- Shroom binds Rock, Rock activates myosin
- regulated by able
- Trio is upregulated in human cancers; involved in cell adhesion/migration
ssh (slingshot)
- phosphotase
- activates tws (twinstar) which is an actin depolymerizer
Candidates which interact directly with actin
fhos
- Formin
- regulates actin filaments
- multiple Fhos genes
- no known medical implications (yet?)
dia (diaphanous)
- formin
- Actin polymerizer (actin nucleator)
- activated by GTPases
- Human health/biology: inner ear: actin structures with hairs
tws (twinstar)
- actin de-polymerizer
- vertebrates: cofilin
- might reduce the amount of actin; OR, by createing free ens cause bursts of actin synthesis!